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Association study of cholesterol-related genes in Alzheimer's disease

Wollmer, M. Axel and Sleegers, Kristel and Ingelsson, Martin and Zekanowski, Cezary and Brouwers, Nathalie and Maruszak, Aleksandra and Brunner, Fabienne and Huynh, Kim-Dung and Kilander, Lena and Brundin, Rose-Marie and Hedlund, Marie and Giedraitis, Vilmantas and Glaser, Anna and Engelborghs, Sebastiaan and De Deyn, Peter P. and Kapaki, Elisabeth and Tsolaki, Magdalini and Daniilidou, Makrina and Molyva, Dimitra and Paraskevas, George P. and Thal, Dietmar R. and Barcikowska, Maria and Kuznicki, Jacek and Lannfelt, Lars and Van Broeckhoven, Christine and Nitsch, Roger M. and Hock, Christoph and Papassotiropoulos, Andreas. (2007) Association study of cholesterol-related genes in Alzheimer's disease. Neurogenetics, Vol. 8, H. 3. pp. 179-188.

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Official URL: http://edoc.unibas.ch/dok/A5257157

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Abstract

Alzheimer's disease (AD) is a genetically complex disorder, and several genes related to cholesterol metabolism have been reported to contribute to AD risk. To identify further AD susceptibility genes, we have screened genes that map to chromosomal regions with high logarithm of the odds scores for AD in full genome scans and are related to cholesterol metabolism. In a European screening sample of 115 sporadic AD patients and 191 healthy control subjects, we analyzed single nucleotide polymorphisms in 28 cholesterol-related genes for association with AD. The genes HMGCS2, FDPS, RAFTLIN, ACAD8, NPC2, and ABCG1 were associated with AD at a significance level of P > or = 0.05 in this sample. Replication trials in five independent European samples detected associations of variants within HMGCS2, FDPS, NPC2, or ABCG1 with AD in some samples (P = 0.05 to P = 0.005). We did not identify a marker that was significantly associated with AD in the pooled sample (n = 2864). Stratification of this sample revealed an APOE-dependent association of HMGCS2 with AD (P = 0.004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:1364-6753
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:32

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