Handle with care: A systematic review on frailty in cardiac care and its usefulness in heart transplantation

Mauthner, Oliver and Claes, Veerle and Deschodt, Mieke and Jha, Sunita R. and Engberg, Sandra and Macdonald, Peter S. and Newton, Phillip J. and De Geest, Sabina. (2017) Handle with care: A systematic review on frailty in cardiac care and its usefulness in heart transplantation. Transplantation reviews, 31 (3). pp. 218-224.

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Official URL: https://edoc.unibas.ch/59848/

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There is growing consensus that frailty, a state of vulnerability and a decline in functioning across multiple physiological body systems, is a valuable criterion to guide clinicians' risk prediction for poor outcomes in adult transplant candidates. In its 2016 listing criteria for heart transplantation the International Society for Heart Lung Transplantation recommends frailty assessment. We aimed to summarize the usefulness of frailty assessment in heart transplant candidates or recipients reported throughout the literature.; We performed a systematic literature search in PubMed to identify papers reporting on frailty in transplantation, chronic heart failure, and ventricualr assist device implantation published over the last 10 years in English. Additionally, a hand search was conducted, including manually searching the reference lists and a citation search of relevant papers.; Eleven primary research articles were included in this systematic review. Frailty is a risk factor for morbidity, hospitalization, and mortality in patients with advanced heart failure and individuals being considered for ventricualr assist device implantation. Of the patients being considered for transplantation, 33% are frail. The Frailty Phenotype by Fried is a particularly useful tool to quickly identify higher risk patients for adverse outcomes.; A lack of standardization and limited evidence on frailty in transplantation limit its use as a definitive listing criterion. Future research efforts should focus on systematic integration of frailty measures in transplant practice.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
UniBasel Contributors:Mauthner, Oliver and Deschodt, Mieke and Engberg, Sandra and De Geest, Sabina M.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Apr 2020 07:00
Deposited On:29 Apr 2020 07:00

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