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Neuroanatomical and functional characterization of the motor circuitry controlling "Drosophila" taste behavior

Schwarz, Olivia. Neuroanatomical and functional characterization of the motor circuitry controlling "Drosophila" taste behavior. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_12565

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Abstract

The precise coordination of body parts is essential for survival and behavior of higher organisms. While progress has been made towards the identification of central mechanisms coordinating limb movement, only limited knowledge exists regarding the generation and execution of sequential motor action patterns at the level of individual motoneurons. Here we use Drosophila proboscis extension as a model system for a reaching-like behavior. We first provide a neuroanatomical description of the motoneurons and muscles contributing to proboscis motion. Using genetic targeting in combination with artificial activation and silencing assays we identify the individual motoneurons controlling the five major sequential steps of proboscis extension and retraction. Activity-manipulations during naturally evoked proboscis extension show that orchestration of serial motoneuron activation does not rely on feed-forward mechanisms. Our data support a model in which central command circuits recruit individual motoneurons to generate task-specific proboscis extension sequences.
Advisors:Arber, Silvia and Pielage, Jan and Reichert, Heinrich
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
UniBasel Contributors:Arber, Silvia and Reichert, Heinrich
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:12565
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (116 Blätter)
Language:English
Identification Number:
Last Modified:18 Apr 2018 13:44
Deposited On:18 Apr 2018 13:17

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