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MicroRNA expression differs in cutaneous squamous cell carcinomas and healthy skin of immunocompetent individuals

Bruegger, Christelle and Kempf, Werner and Spoerri, Iris and Arnold, Andreas W. and Itin, Peter H. and Burger, Bettina. (2013) MicroRNA expression differs in cutaneous squamous cell carcinomas and healthy skin of immunocompetent individuals. Experimental dermatology, 22 (6). pp. 426-428.

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Official URL: https://edoc.unibas.ch/59597/

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Abstract

Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers, but the influence of microRNA (miRNA) expression has only been sporadically analysed. We hypothesized that miRNAs are differentially expressed in cSCC and hence influence its development. We therefore isolated total miRNA from well-differentiated cSCCs and from controls without SCC. Expression analyses of 12 miRNAs showed three significantly differentially expressed miRNAs. We identified a significant upregulation of the miR-21 and the miR-31, a proto-oncogene like miR-21. While the upregulated expression of miR-21 has been known for some time, the increased expression of miR-31 was never shown so clearly. Furthermore, we showed the upregulation of miRNA-205, which has never been described before. The miR-205 induces specific keratinocyte migration and could be a characteristic marker for cSCC. It has to be determined in following studies whether these upregulated expressions are specific for cSCC and if so, for which cSCC stages.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Dermatology (Itin)
UniBasel Contributors:Burger, Bettina
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0906-6705
e-ISSN:1600-0625
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:31 Jan 2018 16:05
Deposited On:31 Jan 2018 16:05

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