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Use of antibody tools to provide serologic evidence of elimination of Lymphatic filariasis in the Gambia

Won, Kimberly Y. and Sambou, Sana and Barry, Amanda and Robinson, Keri and Jaye, Momodou and Sanneh, Bakary and Sanyang, Abdoulie and Gass, Katherine and Lammie, Patrick J. and Rebollo, Maria. (2018) Use of antibody tools to provide serologic evidence of elimination of Lymphatic filariasis in the Gambia. American Journal of Tropical Medicine and Hygiene, 98 (1). pp. 15-20.

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Official URL: https://edoc.unibas.ch/59415/

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Abstract

A current need in the global effort to eliminate lymphatic filariasis (LF) is the availability of reliable diagnostic tools that can be used to guide programmatic decisions, especially decisions made in the final stages of the program. This study conducted in The Gambia aimed to assess antifilarial antibody levels among populations living in historically highly LF-endemic areas and to evaluate the use of serologic tools to confirm the interruption of LF transmission. A total of 2,612 dried blood spots (DBSs) collected from individuals aged 1 year and above from 15 villages were tested for antibodies to Wb123 by enzyme-linked immunosorbent assay (ELISA). A subset of DBS (N = 599) was also tested for antibodies to Bm14 by ELISA. Overall, the prevalence of Wb123 was low (1.5%, 95% confidence interval [CI] 1.1-2.1%). In 7 of 15 villages (46.7%), there were no Wb123-positive individuals identified. Individuals with positive responses to Wb123 ranged in age from 3 to 100 years. Overall, Bm14 prevalence was also low (1.5%, 95% CI 0.7-2.8%). Bm14 positivity was significantly associated with older age (P < 0.001). The low levels of antibody responses to Wb123 observed in our study strongly suggest that sustainable LF transmission has likely ceased in The Gambia. In addition, our results support the conclusion that serologic tools can have a role in guiding programmatic decision making and supporting surveillance.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Won, Kimberly and Won, Kimberly
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society of Tropical Medicine and Hygiene
ISSN:0002-9637
e-ISSN:1476-1645
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:08 Feb 2020 14:49
Deposited On:02 Feb 2018 14:12

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