Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives

Jessen, H. J. and Barbaras, D. and Hamburger, M. and Gademann, K.. (2009) Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives. Organic Letters, 11 (15). pp. 3446-3449.

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Official URL: http://edoc.unibas.ch/dok/A5250907

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An efficient synthesis of all four possible stereoisomers of the neurotrophic amide farinosone C was developed. The absolute and relative configuration was assigned by comparison of synthetic material with a derivatized authentic sample of the natural product. Several derivatives allowed for the generation of preliminary structure activity relationships concerning neurite outgrowth in PC-12 cells, unravelling L-tyrosinol-amide as the pharmacophore.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Nov 2017 10:45
Deposited On:22 Mar 2012 13:32

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