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The Evolutionary Consequences of Stepwise Infection Processes

Hall, Matthew D. and Bento, Gilberto and Ebert, Dieter. (2017) The Evolutionary Consequences of Stepwise Infection Processes. Trends in Ecology & Evolution, 32 (8). pp. 612-623.

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Official URL: https://edoc.unibas.ch/59222/

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Abstract

Molecular and cellular studies reveal that the resistance of hosts to parasites and pathogens is a cascade-like process with multiple steps required to be passed for successful infection. By contrast, much of evolutionary reasoning is based on strongly simplified, one-or two-step infection processes with simple genetics or on resistance being a quantitative trait. Here we attempt a conceptual unification of these two perspectives with the aim of cross-fostering research and filling some of the gaps in our concepts of the ecology and evolution of disease. This conceptual unification has a profound impact on the way we understand the genetics and evolution of host resistance, ecological immunity, evolution of virulence, defence portfolios, and host-pathogen coevolution.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften
05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie > Evolutionary Biology (Ebert)
UniBasel Contributors:Ebert, Dieter and Neves Bento, Gilberto
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Elsevier
ISSN:0169-5347
e-ISSN:1872-8383
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:24 Jul 2020 14:25
Deposited On:24 Jul 2020 14:25

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