Beyond proteome diversity: alternative splicing as a regulator of neuronal transcript dynamics

Mauger, Oriane and Scheiffele, Peter. (2017) Beyond proteome diversity: alternative splicing as a regulator of neuronal transcript dynamics. Current Opinion in Neurobiology, 45. pp. 162-168.

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Official URL: https://edoc.unibas.ch/59172/

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Brain development and function are governed by tightly controlled gene expression programs. Transcriptional repertoires in neurons are highly specific to developmental stage, neuronal cell type and can undergo rapid changes upon neuronal stimulation. Dedicated molecular mechanisms are required to achieve such fine-tuned regulation. In addition to transcriptional programs, post-transcriptional processes and notably alternative splicing substantially contribute to the elaboration of neuronal gene expression. While alternative splicing has been viewed primarily as a means for expanding proteome diversity, it emerges to also be a major regulator of transcript levels and dynamics. In this review we will describe some of the principal alternative splicing-linked mechanisms that control neuronal transcriptomes and discuss their implications for the central nervous system.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Scheiffele)
UniBasel Contributors:Scheiffele, Peter and Mauger, Oriane
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Oct 2018 14:01
Deposited On:19 Oct 2018 14:01

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