A nor-diterpene from Salvia sahendica leaves

Mofidi Tabatabaei, Sahar and Salehi, Peyman and Moridi Farimani, Mahdi and Neuburger, Markus and De Mieri, Maria and Hamburger, Matthias and Nejad-Ebrahimi, Samad. (2017) A nor-diterpene from Salvia sahendica leaves. Natural Product Research, 31 (15). pp. 1758-1765.

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Official URL: http://edoc.unibas.ch/59098/

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Phytochemical investigation of n -hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1 , and known terpenoids, sclareol ( 2 ), oleanolic acid ( 3 ), β-sitosterol ( 4 ), salvigenin ( 5 ) and 3 α -hydroxy-11 α ,12 α -epoxyoleanan-28,13 β -olide ( 6 ). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus , Bacilus cereus and Escherichia coli.
Faculties and Departments:05 Faculty of Science > Departement Chemie
UniBasel Contributors:Neuburger, Markus and de Mieri, Maria and Hamburger, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor & Francis
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 Jan 2018 11:09
Deposited On:24 Jan 2018 11:09

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