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Clinical screening of paraquat in plasma samples using capillary electrophoresis with contactless conductivity detection: Towards rapid diagnosis and therapeutic treatment of acute paraquat poisoning in Vietnam

Vu, Anh Phuong and Nguyen, Thi Ngan and Do, Thi Trang and Doan, Thu Ha and Ha, Tran Hung and Ta, Thi Thao and Nguyen, Hung Long and Hauser, Peter C. and Nguyen, Thi Anh Huong and Mai, Thanh Duc. (2017) Clinical screening of paraquat in plasma samples using capillary electrophoresis with contactless conductivity detection: Towards rapid diagnosis and therapeutic treatment of acute paraquat poisoning in Vietnam. Journal of Chromatography B, 1060. pp. 111-117.

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Official URL: http://edoc.unibas.ch/59007/

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Abstract

The employment of a purpose-made capillary electrophoresis (CE) instrument with capacitively coupled con tactless conductivity detection ((CD)-D-4) as a simple and cost-effective solution for clinical screening of paraquat in plasma samples for early-stage diagnosis of acute herbicide poisoning is reported. Paraquat was determined using an electrolyte composed of 10 mM histidine adjusted to pH 4 with acetic acid. A detection.limit of 0.5 mg/L was achieved. Good agreement between results from CE-(CD)-D-4 and the confirmation method (HPLC-UV) was obtained, with relative errors for the two pairs of data better than 20% for 31 samples taken from paraquat-intoxicated patients. The results were used by medical doctors for identification and prognosis of acute paraquat poisoning cases. The objective of the work is the deployment of the developed approach in rural areas in Vietnam as a low-cost solution to reduce the mortality rate due to accidental or suicidal ingestion of paraquat.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Analytische Chemie (Hauser)
UniBasel Contributors:Hauser, Peter C. P. C.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1570-0232
e-ISSN:1873-376X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:22 Jan 2018 14:33
Deposited On:22 Jan 2018 14:33

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