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Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism

Jeschek, Markus and Panke, Sven and Ward, Thomas R.. (2018) Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism. Trends in Biotechnology, 36 (1). pp. 60-72.

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Official URL: http://edoc.unibas.ch/58963/

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Abstract

Residing at the interface of chemistry and biotechnology, artificial metalloenzymes (ArMs) offer an attractive technology to combine the versatile reaction repertoire of transition metal catalysts with the exquisite catalytic features of enzymes. While earlier efforts in this field predominantly comprised studies in well-defined test-tube environments, a trend towards exploiting ArMs in more complex environments has recently emerged. Integration of these artificial biocatalysts in enzymatic cascades and using them in whole-cell biotransformations and in vivo opens up entirely novel prospects for both preparative chemistry and synthetic biology. We highlight selected recent developments with a particular focus on challenges and opportunities in the in vivo application of ArMs.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R. and Panke, Sven
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0167-7799
e-ISSN:1879-3096
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:20 Feb 2019 11:17
Deposited On:22 Jan 2018 10:56

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