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Cross-Regulation of an Artificial Metalloenzyme

Okamoto, Yasunori and Ward, Thomas R.. (2017) Cross-Regulation of an Artificial Metalloenzyme. Angewandte Chemie International Edition, 56 (34). pp. 10156-10160.

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Abstract

Cross-regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross-regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R. and Okamoto, Yasunori
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1433-7851
e-ISSN:1521-3773
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:22 Jan 2018 10:22
Deposited On:22 Jan 2018 10:22

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