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Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity

Lanzilotto, Angelo and Kyropoulou, Myrto and Constable, Edwin C. and Housecroft, Catherine E. and Meier, Wolfgang P. and Palivan, Cornelia G.. (2018) Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity. Journal of Biological Inorganic Chemistry, 23 (1). pp. 109-122.

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Abstract

A new water-soluble photocatalyst for singlet oxygen generation is presented. Its absorption extends to the red part of the spectrum, showing activity up to irradiation at 660 nm. Its efficiency has been compared to that of a commercial analogue (Rose Bengal) for the oxidation of L-methionine. The quantitative and selective oxidation was promising enough to encapsulate the photocatalyst in polymersomes. The singlet oxygen generated in this way can diffuse and remain active for the oxidation of L-methionine outside the polymeric compartment. These results made us consider the use of these polymersomes for antimicrobial applications. E. Coli colonies were subjected to oxidative stress using the photocatalyst-polymersome conjugates and nearly all the colonies were damaged upon extensive irradiation while under the same red LED light irradiation, liquid cultures in the absence of porphyrin or porphyrin-loaded polymersomes were unharmed
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Anorganische Chemie (Constable)
05 Faculty of Science > Departement Chemie > Chemie > Anorganische Chemie (Housecroft)
UniBasel Contributors:Housecroft, Catherine Elizabeth and Lanzilotto, Angelo and Kyropoulou, Myrto and Constable, Edwin Charles and Meier, Wolfgang P. and Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:0949-8257
e-ISSN:1432-1327
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:15 Jan 2018 10:04
Deposited On:15 Jan 2018 10:04

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