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Influence of loading volume of mefenamic acid on granules and tablet characteristics using a compaction simulator

Kimura, Go and Betz, Gabriele and Leuenberger, Hans. (2007) Influence of loading volume of mefenamic acid on granules and tablet characteristics using a compaction simulator. Pharmaceutical development and technology, Vol. 12, H. 6. pp. 627-635.

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Official URL: http://edoc.unibas.ch/dok/A5248952

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Abstract

Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet charactelistics to be optimized for the loading volume of MA (0-74.1 formulation including lactose monohydrate/maize starch (7/3) as excipients. The compactibility of granules increased with loading volume of MA. This was related to the brittle behavior of MA during compression and the increase of intragranular pore volume of granules. The minimum disintegration time (266 +/- 8.3 s) was found in the tablet that was composed of 55.1 determination of the critical concentration of disintegrant ( required for a minimum disintegration time is suggested to be useful for solid dosage form design.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Industrial Pharmacy Lab (Betz)
UniBasel Contributors:Betz, Gabriele and Kimura, Go
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Marcel Dekker
ISSN:1083-7450
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:32

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