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Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts

Grieder, N. C. and Charlafti, I. and Kloter, U. and Jackle, H. and Schafer, U. and Gehring, W. J.. (2007) Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts. Genetics, 175 (4). pp. 1707-1718.

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Official URL: http://edoc.unibas.ch/dok/A5257277

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Abstract

To identify novel factors that lead a fly imaginal disc to adopt its developmental fate, we carried out a modular dominant misexpression screen in imaginal discs. We have identified two factors that appear to change the fate of the respective body structure and appear to lead to the transformation of a body part. In one mutant line, notum tissue, normally derived from wing imaginal tissue, formed close to the site of the sternopleural bristles, which are leg disc derivatives. In the other line, the arista is transformed into a tubular structure, resembling an abnormal leg. We found that ectopic expression of abrupt was responsible for this potential transformation of the arista.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Gehring)
UniBasel Contributors:Gehring, Walter Jakob
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Genetics Society of America
ISSN:0016-6731
e-ISSN:1943-2631
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:20 Nov 2017 09:52
Deposited On:22 Mar 2012 13:32

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