Simulations for designing and interpreting intervention trials in infectious diseases

Halloran, M. Elizabeth and Auranen, Kari and Baird, Sarah and Basta, Nicole E. and Bellan, Steven E. and Brookmeyer, Ron and Cooper, Ben S. and DeGruttola, Victor and Hughes, James P. and Lessler, Justin and Lofgren, Eric T. and Longini, Ira M. and Onnela, Jukka-Pekka and Özler, Berk and Seage, George R. and Smith, Thomas A. and Vespignani, Alessandro and Vynnycky, Emilia and Lipsitch, Marc. (2017) Simulations for designing and interpreting intervention trials in infectious diseases. BMC medicine, 15. p. 223.

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Official URL: http://edoc.unibas.ch/58377/

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Interventions in infectious diseases can have both direct effects on individuals who receive the intervention as well as indirect effects in the population. In addition, intervention combinations can have complex interactions at the population level, which are often difficult to adequately assess with standard study designs and analytical methods.; Herein, we urge the adoption of a new paradigm for the design and interpretation of intervention trials in infectious diseases, particularly with regard to emerging infectious diseases, one that more accurately reflects the dynamics of the transmission process. In an increasingly complex world, simulations can explicitly represent transmission dynamics, which are critical for proper trial design and interpretation. Certain ethical aspects of a trial can also be quantified using simulations. Further, after a trial has been conducted, simulations can be used to explore the possible explanations for the observed effects.; Much is to be gained through a multidisciplinary approach that builds collaborations among experts in infectious disease dynamics, epidemiology, statistical science, economics, simulation methods, and the conduct of clinical trials.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Smith, Thomas A.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:BioMed Central
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Feb 2018 10:34
Deposited On:02 Feb 2018 10:34

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