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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Demenais, Florence and Margaritte-Jeannin, Patricia and Barnes, Kathleen C. and Cookson, William O. C. and Altmüller, Janine and Ang, Wei and Barr, R. Graham and Beaty, Terri H. and Becker, Allan B. and Beilby, John and Bisgaard, Hans and Bjornsdottir, Unnur Steina and Bleecker, Eugene and Bønnelykke, Klaus and Boomsma, Dorret I. and Bouzigon, Emmanuelle and Brightling, Christopher E. and Brossard, Myriam and Brusselle, Guy G. and Burchard, Esteban and Burkart, Kristin M. and Bush, Andrew and Chan-Yeung, Moira and Chung, Kian Fan and Couto Alves, Alexessander and Curtin, John A. and Custovic, Adnan and Daley, Denise and de Jongste, Johan C. and Del-Rio-Navarro, Blanca E. and Donohue, Kathleen M. and Duijts, Liesbeth and Eng, Celeste and Eriksson, Johan G. and Farrall, Martin and Fedorova, Yuliya and Feenstra, Bjarke and Ferreira, Manuel A. and Gajdos, Zofia and Freidin, Maxim B. and Gauderman, Jim and Gehring, Ulrike and Geller, Frank and Genuneit, Jon and Gharib, Sina A. and Gilliland, Frank and Granell, Raquel and Graves, Penelope E. and Gudbjartsson, Daniel F. and Haahtela, Tari and Heckbert, Susan R. and Heederik, Dick and Heinrich, Joachim and Heliövaara, Markku and Henderson, John and Himes, Blanca E. and Hirose, Hiroshi and Hirschhorn, Joel N. and Hofman, Albert and Holt, Patrick and Hottenga, Jouke and Hudson, Thomas J. and Hui, Jennie and Imboden, Medea and Ivanov, Vladimir and Jaddoe, Vincent W. V. and James, Alan and Janson, Christer and Jarvelin, Marjo-Riitta and Jarvis, Deborah and Jones, Graham and Jonsdottir, Ingileif and Jousilahti, Pekka and Kabesch, Michael and Kähönen, Mika and Kantor, David B. and Karunas, Alexandra S. and Khusnutdinova, Elza and Koppelman, Gerard H. and Kozyrskyj, Anita L. and Kreiner, Eskil and Kubo, Michiaki and Kumar, Rajesh and Kumar, Ashish and Kuokkanen, Mikko and Lahousse, Lies and Laitinen, Tarja and Laprise, Catherine and Lathrop, Mark and Lau, Susanne and Lee, Young-Ae and Lehtimäki, Terho and Letort, Sébastien and Levin, Albert M. and Li, Guo and Liang, Liming and Loehr, Laura R. and London, Stephanie J. and Loth, Daan W. and Manichaikul, Ani and Marenholz, Ingo and Martinez, Fernando J. and Matheson, Melanie C. and Mathias, Rasika A. and Matsumoto, Kenji and Mbarek, Hamdi and McArdle, Wendy L. and Melbye, Mads and Melén, Erik and Meyers, Deborah and Michel, Sven and Mohamdi, Hamida and Musk, Arthur W. and Myers, Rachel A. and Nieuwenhuis, Maartje A. E. and Noguchi, Emiko and O'Connor, George T. and Ogorodova, Ludmila M. and Palmer, Cameron D. and Palotie, Aarno and Park, Julie E. and Pennell, Craig E. and Pershagen, Göran and Polonikov, Alexey and Postma, Dirkje S. and Probst-Hensch, Nicole and Puzyrev, Valery P. and Raby, Benjamin A. and Raitakari, Olli T. and Ramasamy, Adaikalavan and Rich, Stephen S. and Robertson, Colin F. and Romieu, Isabelle and Salam, Muhammad T. and Salomaa, Veikko and Schlünssen, Vivi and Scott, Robert and Selivanova, Polina A. and Sigsgaard, Torben and Simpson, Angela and Siroux, Valérie and Smith, Lewis J. and Solodilova, Maria and Standl, Marie and Stefansson, Kari and Strachan, David P. and Stricker, Bruno H. and Takahashi, Atsushi and Thompson, Philip J. and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Tiesler, Carla M. T. and Torgerson, Dara G. and Tsunoda, Tatsuhiko and Uitterlinden, André G. and van der Valk, Ralf J. P. and Vaysse, Amaury and Vedantam, Sailaja and von Berg, Andrea and von Mutius, Erika and Vonk, Judith M. and Waage, Johannes and Wareham, Nick J. and Weiss, Scott T. and White, Wendy B. and Wickman, Magnus and Widén, Elisabeth and Willemsen, Gonneke and Williams, L. Keoki and Wouters, Inge M. and Yang, James J. and Zhao, Jing Hua and Moffatt, Miriam F. and Ober, Carole and Nicolae, Dan L.. (2018) Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nature Genetics, 50 (1). pp. 42-53.

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Abstract

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Imboden, Medea
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1061-4036
e-ISSN:1546-1718
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:14 Sep 2018 14:38
Deposited On:02 Feb 2018 13:52

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