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Complement in cancer: untangling an intricate relationship

Reis, Edimara S. and Mastellos, Dimitrios C. and Ricklin, Daniel and Mantovani, Alberto and Lambris, John D.. (2018) Complement in cancer: untangling an intricate relationship. Nature reviews. Immunology, 18 (1). pp. 5-18.

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Official URL: http://edoc.unibas.ch/58344/

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Abstract

In tumour immunology, complement has traditionally been considered as an adjunctive component that enhances the cytolytic effects of antibody-based immunotherapies, such as rituximab. Remarkably, research in the past decade has uncovered novel molecular mechanisms linking imbalanced complement activation in the tumour microenvironment with inflammation and suppression of antitumour immune responses. These findings have prompted new interest in manipulating the complement system for cancer therapy. This Review summarizes our current understanding of complement-mediated effector functions in the tumour microenvironment, focusing on how complement activation can act as a negative or positive regulator of tumorigenesis. It also offers insight into clinical aspects, including the feasibility of using complement biomarkers for cancer diagnosis and the use of complement inhibitors during cancer treatment.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ricklin)
UniBasel Contributors:Ricklin, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Nature
ISSN:1474-1733
e-ISSN:1474-1741
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Sep 2018 18:02
Deposited On:15 May 2018 17:54

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