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Prevalence of asthma-like symptoms with ageing

Jarvis, Debbie and Newson, Roger and Janson, Christer and Corsico, Angelo and Heinrich, Joachim and Anto, Josep M. and Abramson, Michael J. and Kirsten, Anne-Marie and Zock, Jan Paul and Bono, Roberto and Demoly, Pascal and Leynaert, Bénédicte and Raherison, Chantal and Pin, Isabelle and Gislason, Thorarinn and Jogi, Rain and Schlunssen, Vivi and Svanes, Cecilie and Watkins, John and Weyler, Joost and Pereira-Vega, Antonio and Urrutia, Isabel and Gullón, Jose A. and Forsberg, Bertil and Probst-Hensch, Nicole and Boezen, H. Marike and Martinez-Moratalla Rovira, Jesús and Accordini, Simone and de Marco, Roberto and Burney, Peter. (2018) Prevalence of asthma-like symptoms with ageing. Thorax, 73. pp. 37-48.

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Abstract

Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy.; The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates.; Over 20 years the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4%, 95% CI -3.5 to -1.3%; -1.5%, 95% CI -2.4 to -0.6%, respectively) but the prevalence of asthma attacks, use of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to 1.11; 3.6%, 95% CI 3.0 to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hay fever/nasal allergies at baseline.; European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:British Medical Association
ISSN:0040-6376
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:26 Apr 2019 15:24
Deposited On:02 Feb 2018 10:08

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