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A Secondary Structural Element in a Wide Range of Fucosylated Glycoepitopes

Aeschbacher, Thomas and Zierke, Mirko and Smieško, Martin and Collot, Mayeul and Mallet, Jean-Maurice and Ernst, Beat and Allain, Frédéric H.-T. and Schubert, Mario. (2017) A Secondary Structural Element in a Wide Range of Fucosylated Glycoepitopes. Chemistry - A European Journal, 23 (48). pp. 11598-11610.

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Official URL: http://edoc.unibas.ch/58313/

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Abstract

The increasing understanding of the essential role of carbohydrates in development, and in a wide range of diseases fuels a rapidly growing interest in the basic principles governing carbohydrate-protein interactions. A still heavily debated issue regarding the recognition process is the degree of flexibility or rigidity of oligosaccharides. Combining NMR structure determination based on extensive experimental data with DFT and database searches, we have identified a set of trisaccharide motifs with a similar conformation that is characterized by a non-conventional C-H⋅⋅⋅O hydrogen bond. These motifs are present in numerous classes of oligosaccharides, found in everything from bacteria to mammals, including Lewis blood group antigens but also unusual motifs from amphibians and marine invertebrates. The set of trisaccharide motifs can be summarized with the consensus motifs X-β1,4-[Fucα1,3]-Y and X-β1,3-[Fucα1,4]-Y-a secondary structure we name [3,4]F-branch. The wide spectrum of possible modifications of this scaffold points toward a large variety of glycoepitopes, which nature generated using the same underlying architecture.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ernst)
UniBasel Contributors:Ernst, Beat and Zierke, Mirko and Smiesko, Martin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0947-6539
e-ISSN:1521-3765
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 May 2018 15:32
Deposited On:28 May 2018 15:32

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