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Coupling termination of transcription to messenger RNA maturation in yeast

Birse, C. E. and Minvielle-Sebastia, L. and Lee, B. A. and Keller, W. and Proudfoot, N. J.. (1998) Coupling termination of transcription to messenger RNA maturation in yeast. Science, 280 (5361). pp. 298-301.

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Official URL: http://edoc.unibas.ch/dok/A5257957

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Abstract

The direct association between messenger RNA (mRNA) 3'-end processing and the termination of transcription was established for the CYC1 gene of Saccharomyces cerevisiae. The mutation of factors involved in the initial cleavage of the primary transcript at the poly(A) site (RNA14, RNA15, and PCF11) disrupted transcription termination at the 3' end of the CYC1 gene. In contrast, the mutation of factors involved in the subsequent polyadenylation step (PAP1, FIP1, and YTH1) had little effect. Thus, cleavage factors link transcription termination of RNA polymerase II with pre-mRNA 3'-end processing.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Keller)
UniBasel Contributors:Keller, Walter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
e-ISSN:1095-9203
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:08 Nov 2017 07:11
Deposited On:22 Mar 2012 13:31

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