De Marchis, Gian Marco and Katan, Mira and Barro, Christian and Fladt, Joachim and Traenka, Christopher and Seiffge, David J. and Hert, Lisa and Gensicke, Henrik and Disanto, Giulio and Sutter, Raoul and Peters, Nils and Sarikaya, Hakan and Goeggel-Simonetti, Barbara and El-Koussy, Marwan and Engelter, Stephan and Lyrer, Philippe A. and Christ-Crain, Mirjam and Arnold, Marcel and Kuhle, Jens and Bonati, Leo H..
(2018)
Serum neurofilament light chain in patients with acute cerebrovascular events.
European Journal of Neurology, 25 (3).
pp. 562-568.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/58234/
Downloads: Statistics Overview
Abstract
BACKGROUND AND PURPOSE: Serum Neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) transient ischemic attack (TIA). METHODS: Nested within a prospective cohort study, we compared levels of serum neurofilament light chain (sNfL) drawn within 24 h from symptom onset in patients with AIS or TIA. Patients without magnetic resonance imaging on admission were excluded. We assessed whether sNfL was associated with: (i) clinical severity on admission, (ii) diagnosis of AIS vs. TIA, (iii) infarct size on admission magnetic resonance diffusion-weighted imaging (MRDWI) and (iv) functional outcome at 3 months. RESULTS: We analyzed 504 patients with AIS and 111 patients with TIA. On admission, higher National Institutes of Health Stroke Scale (NIHSS) scores were associated with higher sNfL: NIHSS score < 7, 13.1 pg/mL [interquartile range (IQR), 5.3–27.8]; NIHSS score 7–15, 16.7 pg/mL (IQR, 7.4–34.9); and NIHSS score > 15, 21.0 pg/mL (IQR, 9.3–40.4) (P = 0.01). Compared with AIS, patients with TIA had lower sNfL levels [9.0 pg/mL (95% confidence interval, 4.0–19.0) vs. 16.0 pg/mL (95% confidence interval, 7.3–34.4), P < 0.001], also after adjusting for age and NIHSS score (P = 0.006). Among patients with AIS, infarct size on admission MR-DWI was not associated with sNfL, either in univariate analysis (P = 0.15) or after adjusting for age and NIHSS score on admission (P = 0.56). Functional outcome 3 months after stroke was not associated with sNfL after adjusting for established predictors. CONCLUSIONS: In conclusion, among patients admitted within 24 hours of AIS or TIA onset, admission sNfL levels were associated with clinical severity on admission and TIA diagnosis, but not with infarct size on MR-DWI acquired on admission or functional outcome at 3 months.
Faculties and Departments: | 03 Faculty of Medicine 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Intensivmedizin > Intensivmedizin (Marsch) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Intensivmedizin > Intensivmedizin (Marsch) 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie |
---|
UniBasel Contributors: | Sutter, Raoul Christian |
---|
Item Type: | Article, refereed |
---|
Article Subtype: | Research Article |
---|
Publisher: | Wiley |
---|
ISSN: | 1351-5101 |
---|
e-ISSN: | 1468-1331 |
---|
Note: | Publication type according to Uni Basel Research Database: Journal article |
---|
Identification Number: | |
---|
Last Modified: | 15 May 2018 16:57 |
---|
Deposited On: | 15 May 2018 16:57 |
---|
Repository Staff Only: item control page