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Impact of irregular sleep patterns on emotion regulation and cognitive flexibility in patients with major depression and in healthy controls

Mikoteit, T. and Maier, F. and Miché, M. and Wersebe, H. and Imboden, C. and Hatzinger, M. and Holsboer-Trachsler, E. and Lieb, R. and Gloster, A.. (2017) Impact of irregular sleep patterns on emotion regulation and cognitive flexibility in patients with major depression and in healthy controls. Pharmacopsychiatry, 50 (05 ). pp. 213-227.

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Official URL: http://edoc.unibas.ch/57895/

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Abstract

Emotion regulation (ER) and cognitive flexibility (CF) are often impaired in major depression (MDD). Therefore, both ER and CF have become the focus of novel psychotherapeutic approaches. Further, emotional and cognitive daytime performances may vary as a function of nocturnal sleep. Accordingly, the aim of the present study was to examine the influence of subjective and objective sleep quality on ER and CF in patients with MDD, compared to healthy controls. Severity of depression, ER, CF and subjective insomnia were assessed with questionnaires in 118 out-patients with MDD (age: M = 32.7, SD = 12.1; 66.1% females) and in 119 healthy controls. Additionally, sleep was objectively assessed with actimetry over seven consecutive nights. Compared to healthy controls, patients with MDD presented decreased ER and CF, higher scores of self-rated insomnia, and decreased objective sleep quality. In both groups, poor subjective sleep correlated with increased impulsivity and decreased CF. Further, a higher day-to-day variability of objective sleep efficiency correlated with higher impulsivity in both groups, and with decreased CF in patients with MDD. The pattern of results suggests that regular and restoring sleep is associated with favourable ER and CF; this holds particularly true for patients with MDD. Further, we claim that psychotherapeutic interventions to improve both ER and CF in patients with MDD would further benefit from interventions to reduce poor sleep.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Miché, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Georg Thieme Verlag
ISSN:0031-7098
e-ISSN:1439-0795
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:29 May 2018 14:18
Deposited On:29 May 2018 14:18

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