Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)−H Carbamoylation

Dailler, David and Rocaboy, Ronan and Baudoin, Olivier. (2017) Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)−H Carbamoylation. Angewandte Chemie International Edition, 56 (25). pp. 7218-7222.

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Official URL: http://edoc.unibas.ch/57663/

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A general and user-friendly synthesis of beta-lactams is reported that makes use of Pd-0-catalyzed carbamoylation of C(sp(3))-H bonds, and operates under stoichiometric carbon monoxide in a two-chamber reactor. This reaction is compatible with a range of primary, secondary and activated tertiary C-H bonds, in contrast to previous methods based on C(sp(3))-H activation. In addition, the feasibility of an enantio-selective version using a chiral phosphonite ligand is demonstrated. Finally, this method can be employed to synthesize valuable enantiopure free beta-lactams and beta-amino acids.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische Chemie (Baudoin)
UniBasel Contributors:Baudoin, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article -- The final publication ist available at Wiley, see DOI link
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Last Modified:17 Aug 2018 12:15
Deposited On:20 Dec 2017 08:44

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