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Enantioselective α-Arylation of O-Carbamates via Sparteine-Mediated Lithiation and Negishi Cross-Coupling

Royal, Titouan and Baumgartner, Yann and Baudoin, Olivier. (2017) Enantioselective α-Arylation of O-Carbamates via Sparteine-Mediated Lithiation and Negishi Cross-Coupling. Organic Letters, 19 (1). pp. 166-169.

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Abstract

A general and highly enantioselective arylation of carbamates derived from primary alcohols was developed by combining Hoppe’s sparteine-mediated asymmetric lithiation with Negishi cross-coupling. Coupled with Aggarwal’s lithiation–borylation sequence, the current method provides a short and divergent access to a variety of enantioenriched secondary and tertiary benzylic alcohols.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische Chemie (Baudoin)
UniBasel Contributors:Baudoin, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1523-7060
e-ISSN:1523-7052
Note:Publication type according to Uni Basel Research Database: Journal article -- The final publication is available at ACS, see DOI link
Language:English
Identification Number:
Last Modified:17 Aug 2018 12:07
Deposited On:20 Dec 2017 08:38

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