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Cyclic di-GMP: second messenger extraordinaire

Jenal, Urs and Reinders, Alberto and Lori, Christian. (2017) Cyclic di-GMP: second messenger extraordinaire. Nature Reviews Microbiology, 15 (5). pp. 271-284.

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Official URL: http://edoc.unibas.ch/57597/

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Abstract

Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP). Known since the late 1980s, it is now recognized as a near-ubiquitous second messenger that coordinates diverse aspects of bacterial growth and behaviour, including motility, virulence, biofilm formation and cell cycle progression. In this Review, we discuss important new insights that have been gained into the molecular principles of c-di-GMP synthesis and degradation, which are mediated by diguanylate cyclases and c-di-GMP-specific phosphodiesterases, respectively, and the cellular functions that are exerted by c-di-GMP-binding effectors and their diverse targets. Finally, we provide a short overview of the signalling versatility of other CDNs, including c-di-AMP and cGMP-AMP (cGAMP).
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development
05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Jenal)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Molecular Microbiology (Jenal)
05 Faculty of Science > Departement Biozentrum > Infection Biology
UniBasel Contributors:Jenal, Urs and Reinders, Alberto and Lori, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1740-1526
e-ISSN:1740-1534
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:14 Dec 2017 10:43
Deposited On:14 Dec 2017 10:42

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