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Potential of Bryophyllum pinnatum as a detrusor relaxant: an in vitro exploratory study

Bachmann, Simon and Betschart, Cornelia and Hamburger, Matthias and Fürer, Karin and Mennet, Mónica and von Mandach, Ursula and Potterat, Olivier and Simões-Wüst, Ana Paula and Gerber, Julia . (2017) Potential of Bryophyllum pinnatum as a detrusor relaxant: an in vitro exploratory study. Planta Medica, 83 (16). pp. 1274-1280.

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Official URL: http://edoc.unibas.ch/57595/

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Abstract

An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. B. pinnatum leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of B. pinnatum leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with B. pinnatum.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias and Potterat, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Georg Thieme Verlag
ISSN:0032-0943
e-ISSN:1439-0221
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 May 2018 07:10
Deposited On:30 May 2018 07:10

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