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Susceptibility to mycobacterium ulcerans disease (buruli ulcer) is associated with IFNG and iNOS gene polymorphisms

Bibert, Stéphanie and Bratschi, Martin W. and Aboagye, Samuel Y. and Collinet, Emilie and Scherr, Nicole and Yeboah-Manu, Dorothy and Beuret, Christian and Pluschke, Gerd and Bochud, Pierre-Yves. (2017) Susceptibility to mycobacterium ulcerans disease (buruli ulcer) is associated with IFNG and iNOS gene polymorphisms. Frontiers in Microbiology, 8. p. 1903.

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Official URL: http://edoc.unibas.ch/57507/

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Abstract

Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Otherwise, bacterial multiplication leads to in higher concentrations of mycolactone, with formation of necrotizing lesions that are no more accessible to immune cells. By typing a cohort of 96 Ghanaian BU patients and 384 endemic controls without BU, we show an association between BU and single nucleotide polymorphisms (SNPs) in iNOS (rs9282799) and IFNG (rs2069705). Both polymorphisms influence promoter activity in vitro. A previously reported SNP in SLC11A1 (NRAMP, rs17235409) tended to be associated with BU. Altogether, these data reflect the importance of IFNG signaling in early defense against M. ulcerans infection.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Bratschi, Martin and Scherr, Nicole and Pluschke, Gerd
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
e-ISSN:1664-302X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Dec 2017 12:45
Deposited On:21 Dec 2017 12:45

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