Comparative effectiveness research: Using systematic reviews and meta-analyses to synthesize empirical evidence

Katapodi, Maria C. and Northouse, Laurel L.. (2011) Comparative effectiveness research: Using systematic reviews and meta-analyses to synthesize empirical evidence. Research and theory for nursing practice, 25 (3). pp. 191-209.

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Official URL: http://edoc.unibas.ch/57040/

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The increased demand for evidence-based health care practices calls for comparative effectiveness research (CER), namely the generation and synthesis of research evidence to compare the benefits and harms of alternative methods of care. A significant contribution of CER is the systematic identification and synthesis of available research studies on a specific topic. The purpose of this article is to provide an overview of methodological issues pertaining to systematic reviews and meta-analyses to be used by investigators with the purpose of conducting CER. A systematic review or meta-analysis is guided by a research protocol, which includes (a) the research question, (b) inclusion and exclusion criteria with respect to the target population and studies, (c) guidelines for obtaining relevant studies, (d) methods for data extraction and coding, (e) methods for data synthesis, and (f) guidelines for reporting results and assessing for bias. This article presents an algorithm for generating evidence-based knowledge by systematically identifying, retrieving, and synthesizing large bodies of research studies. Recommendations for evaluating the strength of evidence, interpreting findings, and discussing clinical applicability are offered.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Ehemalige Einheiten Public Health > Pflegewissenschaft (Katapodi)
UniBasel Contributors:Katapodi, Maria C.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Publishing Company
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:31 Jan 2018 13:13
Deposited On:31 Jan 2018 13:13

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