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Symptoms and characteristics of individuals with profound hyponatremia: a prospective multicenter observational study

Nigro, N. and Winzeler, B. and Suter-Widmer, I. and Schuetz, P. and Arici, B. and Bally, M. and Blum, C. and Bingisser, R. and Bock, A. and Huber, A. and Muller, B. and Nickel, C. H. and Christ-Crain, M.. (2015) Symptoms and characteristics of individuals with profound hyponatremia: a prospective multicenter observational study. Journal of the American Geriatrics Society, 63 (3). pp. 470-475.

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Official URL: http://edoc.unibas.ch/56860/

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Abstract

OBJECTIVES: To assess symptoms and characteristics of hyponatremia, the most common electrolyte disturbance in hospitalized individuals and a condition that is associated with substantial morbidity and mortality. DESIGN: Prospective observational multicenter study. SETTING: Two Swiss academic centers. PARTICIPANTS: Individuals with profound hypoosmolar hyponatremia (sodium>125 mmol/L) (N=298). MEASUREMENTS: All symptoms and complete medical history including current medications, therapy management, and in-hospital outcomes were recorded. RESULTS: The median age of all participants was 71 (interquartile range (IQR) 60-80), 195 (65%) were female, and mean serum sodium value on admission was 120 mmol/L (IQR 116-123 mmol/L). Frequent clinical symptoms were nausea (n=130, 44%), acute vomiting (n=91, 30%), generalized weakness (n=205, 69%), fatigue (n=175, 59%), gait disturbance (n=92, 31%), recurrent falls (n=47, 16%), and acute falls (n=60, 20%). Fractures were reported in 11 participants (4%). More-severe symptoms such as acute epileptic seizures and focal neurological deficits were identified in 16 (5%) and 17 (5%) participants, respectively. The most common comorbidities were hypertension (n=199, 67%), congestive heart failure (n=44, 15%), chronic renal failure (n=64, 21%), pulmonary disease (82, 28%), and central nervous system disease (n=114, 38%). During hospitalization, 12 (4%) participants died, and 103 (35%) needed treatment in the intensive care unit. CONCLUSION: A wide spectrum of symptoms accompanies profound hyponatremia. Most participants had moderate symptoms mirroring chronic hyponatremia with brain cell adaptation. Participants with profound hyponatremia had several comorbidities.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin AG > Argovia Professur für Medizin (Müller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin AG > Argovia Professur für Medizin (Müller)
UniBasel Contributors:Müller, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0002-8614
e-ISSN:1532-5415
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Dec 2017 11:04
Deposited On:04 Dec 2017 11:04

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