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The habenula as a critical node in chronic stress-related anxiety

Jacinto, Luis R. and Mata, Rui and Novais, Ashley and Marques, Fernanda and Sousa, Nuno. (2017) The habenula as a critical node in chronic stress-related anxiety. Experimental neurology, 289. pp. 46-54.

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Official URL: http://edoc.unibas.ch/56524/

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Abstract

The habenula is activated in response to stressful and aversive events, resulting in exploratory inhibition. Although possible mechanisms for habenula activation have been proposed, the effects of chronic stress on the habenular structure have never been studied. Herein, we assessed changes in volume, cell density and dendritic structure of habenular cells after chronic stress exposure using stereological and 3D morphological analysis. This study shows for the first time that there is a hemispherical asymmetry in the medial habenula (MHb) of the adult rat, with the right MHb containing more neurons than its left counterpart. Additionally, it shows that chronic stress induces a bilateral atrophy of both the MHb and the lateral habenula (LHb). This atrophy was accompanied by a reduction of the number of neurons in the right MHb and the number of glial cells in the bilateral LHb, but not by changes in the dendritic arbors of multipolar neurons. Importantly, these structural changes were correlated with elevated levels of serum corticosterone and increased anxious-like behavior in stressed animals. To further assess the role of the habenula in stress-related anxiety, bilateral lesions of the LHb were performed; interestingly, in lesioned animals the chronic stress protocol did not trigger increases in circulating corticosterone or anxious-like behavior. This study highlights the role of the habenula in the stress responses and how its sub-regions are structurally impacted by chronic stress with physiological and behavioral consequences.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Sozial-, Wirtschafts- und Entscheidungspsychologie > Cognitive and Decision Sciences (Mata)
UniBasel Contributors:Mata, Rui
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Academic Press
ISSN:0014-4886
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Jun 2018 15:29
Deposited On:07 Jun 2018 15:29

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