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Engineering cell-based patches as controlled VEGF-releasing devices for therapeutic angiogenesis

Gaudiello, Emanuele. Engineering cell-based patches as controlled VEGF-releasing devices for therapeutic angiogenesis. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_12378

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Abstract

An adequate reperfusion of the infarcted tissue remains a formidable challenge in the management of myocardial infarction. The concept of inducing angiogenesis for a therapeutic purpose aims at meeting this specific clinical need. for over 15 years direct delivery of VEGF by a gene therapy approach has been the most investigated strategy and, although promising, presents still major limitations, due to the inefficiency of current transgene vectors in guaranteeing adequate and sustained expression levels of the VEGF triggering safe, mature and stable angiogenesis. In this thesis we investigated the use of engineered tissues as VEGF delivery system to trigger an efficient pro-angiogenic signal able to induce a safe and mature vasculature.
Advisors:Affolter, Markus and Banfi, Andrea and Ehrbar, Martin
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus and Banfi, Andrea
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:12378
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (III, 111 Seiten)
Language:English
Identification Number:
Last Modified:22 Jan 2018 15:53
Deposited On:27 Nov 2017 15:49

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