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Stability of medicines after repackaging into multicompartment compliance aids: eight criteria for detection of visual alteration

Albert, Valerie and Lanz, Michael and Imanidis, Georgios and Hersberger, Kurt E. and Arnet, Isabelle. (2017) Stability of medicines after repackaging into multicompartment compliance aids: eight criteria for detection of visual alteration. Drugs & Therapy Perspectives, 33 (10). pp. 487-496.

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Official URL: http://edoc.unibas.ch/56343/

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Abstract

Multicompartment compliance aids (MCA) are widely used by patients. They support the management of medication and reduce unintentional nonadherence. MCA are filled with medicines unpacked from their original packaging. Swiss pharmacists currently provide MCA for 1-2 weeks, although little and controversial information exists on the stability of repackaged medicines.; We aimed to validate the usefulness of a simple screening method capable of detecting visual stability problems with repackaged medicines.; We selected eight criteria for solid formulations from The International Pharmacopoeia: (1) rough surface, (2) chipping, (3) cracking, (4) capping, (5) mottling, (6) discoloration, (7) swelling, and (8) crushing. A selection of 24 critical medicines was repackaged in three different MCA (Pharmis(®), SureMed™, and self-produced blister) and stored at room temperature for 4 weeks. Pharmis(®) was additionally stored at accelerated conditions. Appearance was scored weekly.; Six alterations (rough surface, cracking, mottling, discoloration, swelling, and crushing) were observed at accelerated conditions. No alteration was observed at room temperature, except for the chipping of tablets that had been stuck to cold seal glue.; The eight criteria can detect alterations of the appearance of oral solid medicines repackaged in MCA. In the absence of specific guidelines, they can serve as a simple screening method in community pharmacies for identifying medicines unsuitable for repackaging.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Care (Hersberger)
UniBasel Contributors:Arnet, Isabelle and Wentzky, Valerie and Hersberger, Kurt E.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:1172-0360
e-ISSN:1179-1977
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Oct 2017 10:00
Deposited On:23 Oct 2017 10:00

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