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Heterogeneity of Salmonella-host interactions in infected host tissues

Bumann, Dirk and Cunrath, Olivier. (2017) Heterogeneity of Salmonella-host interactions in infected host tissues. Current Opinion in Microbiology, 39. pp. 57-63.

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Abstract

Infected host tissues have complex anatomy, diverse cell types, and dynamic inflammation. Traditional infection biology approaches largely ignore this complex host environment and its impact on pathogens, but recent single-cell technologies unravel extensively heterogeneous host-pathogen interactions in vivo. Salmonella are major model pathogens in this field due to the availability of excellent mouse disease models and facile molecular biology. The results show how Salmonella stochastically vary their virulence, exploit differential nutrient availability, experience and respond to widely varying stresses, and have disparate fates ranging from vigorous proliferation to eradication within the same host tissue. Specific Salmonella subsets drive disease progression, while others persist during antimicrobial chemotherapy. Further elucidation of the underlying mechanisms could provide a basis for improved infection control.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk and Cunrath, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1369-5274
e-ISSN:1879-0364
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:23 Nov 2018 15:46
Deposited On:13 Oct 2017 07:52

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