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The pharmacology of d-Lysergic acid diethylamide (LSD)

Dolder, Patrick. The pharmacology of d-Lysergic acid diethylamide (LSD). 2017, Doctoral Thesis, University of Basel, Faculty of Medicine.

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Official URL: http://edoc.unibas.ch/diss/DissB_12502

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Abstract

My PhD thesis consisted of two different scientific parts, each supervised by one of my advisors, Prof. Dr. med. Matthias Liechti and Prof. Dr. sc. nat. Katharina Rentsch. One part was to develop liquid chromatography tandem mass spectrometry (LC-MS/MS) methods to measure d-lysergic acid diethylamide (LSD) and its main metabolites in plasma, serum, and urine samples. We established the pharmacokinetics of LSD and collected data from emergency toxicological cases. Therefore we have developed and validated two analytical methods using LC-MS/MS which resulted in several publications. All analytical work was performed in the Toxicology Lab of the Laboratory Medicine at the University Hospital Basel under the supervision of Prof. Dr. sc. nat. Katharina Rentsch. The second part included planning, conduction, and analysis of clinical phase I trials with LSD. We investigated the acute psychological and physiological effects of LSD in healthy humans what resulted in several publication. These projects were supervised by Prof. Dr. med. Matthias Liechti at the Department of Clinical Pharmacology and Toxicology of the University Hospital Basel. One LSD study included a functional magnetic resonance imaging (fMRI) assessment, to investigate the neural correlates of altered states of consciousness and emotion processing under the influence of LSD. The fMRI study was done in close collaboration with the team of Prof. Dr. med. Stefan Borgwardt from the Department of Psychiatry of the University of Basel.
Advisors:Liechti, Matthias Emanuel and Rentsch, Katharina and Borgwardt, Stefan and Weinmann, Wolfgang and Krähenbühl, Stephan
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Psychopharmacology Research (Liechti)
UniBasel Contributors:Dolder, Patrick and Liechti, Matthias Emanuel and Rentsch, Katharina and Borgwardt, Stefan and Krähenbühl, Stephan
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:12502
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (129 Seiten)
Language:English
Identification Number:
Last Modified:22 Apr 2018 04:32
Deposited On:03 Apr 2018 09:08

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