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RTS,S/AS01E malaria vaccine induces memory and polyfunctional T cell responses in a pediatric african phase III trial

Moncunill, Gemma and De Rosa, Stephen C. and Ayestaran, Aintzane and Nhabomba, Augusto J. and Mpina, Maximillian and Cohen, Kristen W. and Jairoce, Chenjerai and Rutishauser, Tobias and Campo, Joseph J. and Harezlak, Jaroslaw and Sanz, Héctor and Díez-Padrisa, Núria and Williams, Nana Aba and Morris, Daryl and Aponte, John J. and Valim, Clarissa and Daubenberger, Claudia and Dobaño, Carlota and McElrath, M. Juliana. (2017) RTS,S/AS01E malaria vaccine induces memory and polyfunctional T cell responses in a pediatric african phase III trial. Frontiers in Immunology, 8. p. 1008.

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Official URL: http://edoc.unibas.ch/56137/

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Abstract

Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg) were assessed before and 1 month after primary vaccination by intracellular cytokine staining and 16-color flow cytometry in 105 RTS,S/AS01-vaccinated and 74 rabies-vaccinated participants (controls) in a pediatric phase III trial in Africa. RTS,S/AS01E-vaccinated children had significantly higher frequencies of CSP- and HBsAg-specific CD4(+) T cells producing IL-2, TNF-α, and CD40L and HBsAg-specific CD4(+) T producing IFN-γ and IL-17 than baseline and the control group. Vaccine-induced responses were identified in both central and effector memory (EM) compartments. EM CD4(+) T cells expressing IL-4 and IL-21 were detected recognizing both vaccine antigens. Consistently higher response rates to both antigens in RTS,S/AS01E-vaccinated than comparator-vaccinated children were observed. RTS,S/AS01E induced polyfunctional CSP- and HBsAg-specific CD4(+) T cells, with a greater degree of polyfunctionality in HBsAg responses. In conclusion, RTS,S/AS01E vaccine induces T cells of higher functional heterogeneity and polyfunctionality than previously characterized. Responses detected in memory CD4(+) T cell compartments may provide correlates of RTS,S/AS01-induced immunity and duration of protection in future correlates of immunity studies.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Clinical Immunology (Daubenberger)
UniBasel Contributors:Daubenberger, Claudia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
e-ISSN:1664-3224
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Oct 2017 09:55
Deposited On:03 Oct 2017 09:55

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