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X-ray micro computed tomography for the visualization of an atherosclerotic human coronary artery

Matviykiv, Sofiya and Buscema, Marzia and Deyhle, Hans and Pfohl, Thomas and Zumbuehl, Andreas and Saxer, Till and Muller, Bert. (2017) X-ray micro computed tomography for the visualization of an atherosclerotic human coronary artery. In: Journal of Physics: Conference Series , 849.

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Official URL: http://edoc.unibas.ch/56107/

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Abstract

Atherosclerosis refers to narrowing or blocking of blood vessels that can lead to a heart attack, chest pain or stroke. Constricted segments of diseased arteries exhibit considerably increased wall shear stress, compared to the healthy ones. One of the possibilities to improve patient's treatment is the application of nano-therapeutic approaches, based on shear stress sensitive nano-containers. In order to tailor the chemical composition and subsequent physical properties of such liposomes, one has to know precisely the morphology of critically stenosed arteries at micrometre resolution. It is often obtained by means of histology, which has the drawback of offering only two-dimensional information. Additionally, it requires the artery to be decalcified before sectioning, which might lead to deformations within the tissue. Micro computed tomography (muCT) enables the three-dimensional (3D) visualization of soft and hard tissues at micrometre level. muCT allows lumen segmentation that is crucial for subsequent flow simulation analysis. In this communication, tomographic images of a human coronary artery before and after decalcification are qualitatively and quantitatively compared. We analyse the cross section of the diseased human coronary artery before and after decalcification, and calculate the lumen area of both samples.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedical Engineering > Biomechanics and Biomaterials
05 Faculty of Science > Departement Chemie > Chemie > Biophysikalische Chemie (Pfohl)
UniBasel Contributors:Pfohl, Thomas
Item Type:Conference or Workshop Item, refereed
Conference or workshop item Subtype:Conference Paper
Publisher:IOP Publishing
ISSN:1742-6588
e-ISSN:1742-6596
Note:Publication type according to Uni Basel Research Database: Conference paper
Language:English
Identification Number:
Last Modified:18 Sep 2017 08:27
Deposited On:18 Sep 2017 08:27

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