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Picture free recall performance linked to the brain's structural connectome

Coynel, David and Gschwind, Leo and Fastenrath, Matthias and Freytag, Virginie and Milnik, Annette and Spalek, Klara and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.. (2017) Picture free recall performance linked to the brain's structural connectome. Brain and Behavior, 7 (7). e00721.

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Abstract

Memory functions are highly variable between healthy humans. The neural correlates of this variability remain largely unknown.; Here, we investigated how differences in free recall performance are associated with DTI-based properties of the brain's structural connectome and with grey matter volumes in 664 healthy young individuals tested in the same MR scanner.; Global structural connectivity, but not overall or regional grey matter volumes, positively correlated with recall performance. Moreover, a set of 22 inter-regional connections, including some with no previously reported relation to human memory, such as the connection between the temporal pole and the nucleus accumbens, explained 7.8% of phenotypic variance.; In conclusion, this large-scale study indicates that individual memory performance is associated with the level of structural brain connectivity.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
UniBasel Contributors:Coynel, David and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley Open Access
ISSN:2162-3279
e-ISSN:2157-9032
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:25 Jun 2018 15:59
Deposited On:20 Nov 2017 13:36

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