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Intracellular Salmonella metabolism

Bumann, Dirk and Schothorst, Joep. (2017) Intracellular Salmonella metabolism. Cellular Microbiology, 19 (10). e12766.

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Abstract

Growth of Salmonella inside infected host cells is a key aspect of their ability to cause local enteritis or systemic disease. This growth depends on exploitation of host nutrients through a large Salmonella metabolism network with hundreds of metabolites and enzymes. Studies in cell culture infection models are unraveling more and more of the underlying molecular and cellular mechanisms, but also show striking Salmonella metabolic plasticity depending on host cell line and experimental conditions. In vivo studies have revealed a qualitatively diverse, but quantitatively poor, host-Salmonella nutritional interface, which on one side makes Salmonella fitness largely resilient against metabolic perturbations, but on the other side severely limits Salmonella biomass generation and growth rates. This review discusses goals and techniques for studying Salmonella intracellular metabolism, summarizes main results and implications, and proposes key issues that could be addressed in future studies.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk and Schothorst, Joep
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1462-5814
e-ISSN:1462-5822
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:07 Dec 2018 15:50
Deposited On:19 Oct 2017 09:11

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