edoc

Excretory/secretory products from the gastrointestinal nematode Trichuris muris

Tritten, Lucienne and Tam, Mifong and Vargas, Mireille and Jardim, Armando and Stevenson, Mary M. and Keiser, Jennifer and Geary, Timothy G.. (2017) Excretory/secretory products from the gastrointestinal nematode Trichuris muris. Experimental parasitology, 178. pp. 30-36.

[img] PDF
Restricted to Repository staff only

710Kb

Official URL: http://edoc.unibas.ch/55499/

Downloads: Statistics Overview

Abstract

To better control gastrointestinal nematode infections in humans and animals, it is important to understand the strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We characterized the excretory/secretory (E/S) microRNA (miRNA) and protein profiles from the mouse gastrointestinal nematode parasite Trichuris muris. Released miRNAs were subjected to miRNA sequencing and E/S proteins were analysed by mass spectrometry. Fourteen miRNAs were identified in T. muris exosome-like vesicles, as well as 73 proteins of nematode origin, 11 of which were unique to this study. Comparison with published nematode protein secretomes revealed high conservation at the functional level.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Vargas, Mireille and Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1090-2449
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:12 Apr 2018 08:18
Deposited On:06 Dec 2017 12:54

Repository Staff Only: item control page