edoc

Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study

Brady, Oliver J. and Slater, Hannah C. and Pemberton-Ross, Peter James and Wenger, Edward and Maude, Richard J. and Ghani, Azra C. and Penny, Melissa A. and Gerardin, Jaline and White, Lisa J. and Chitnis, Nakul and Aguas, Ricardo and Hay, Simon I. and Smith, David L. and Stuckey, Erin M. and Okiro, Emelda A and Smith, Thomas A. and Okell, Lucy C.. (2017) Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study. Lancet Glob Health, 5 (7). e680-e687.

[img]
Preview
PDF - Published Version
Available under License CC BY (Attribution).

1187Kb

Official URL: http://edoc.unibas.ch/55447/

Downloads: Statistics Overview

Abstract

Background: Mass drug administration for elimination of Plasmodium falciparum malaria is recommended by WHO in some settings. We used consensus modelling to understand how to optimise the effects of mass drug administration in areas with low malaria transmission.
Methods: We collaborated with researchers doing field trials to establish a standard intervention scenario and standard transmission setting, and we input these parameters into four previously published models. We then varied the number of rounds of mass drug administration, coverage, duration, timing, importation of infection, and pre-administration transmission levels. The outcome of interest was the percentage reduction in annual mean prevalence of P falciparum parasite rate as measured by PCR in the third year after the final round of mass drug administration.
Findings: The models predicted differing magnitude of the effects of mass drug administration, but consensus answers were reached for several factors. Mass drug administration was predicted to reduce transmission over a longer timescale than accounted for by the prophylactic effect alone. Percentage reduction in transmission was predicted to be higher and last longer at lower baseline transmission levels. Reduction in transmission resulting from mass drug administration was predicted to be temporary, and in the absence of scale-up of other interventions, such as vector control, transmission would return to pre-administration levels. The proportion of the population treated in a year was a key determinant of simulated effectiveness, irrespective of whether people are treated through high coverage in a single round or new individuals are reached by implementation of several rounds. Mass drug administration was predicted to be more effective if continued over 2 years rather than 1 year, and if done at the time of year when transmission is lowest.
Interpretation: Mass drug administration has the potential to reduce transmission for a limited time, but is not an effective replacement for existing vector control. Unless elimination is achieved, mass drug administration has to be repeated regularly for sustained effect.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Infectious Disease Modelling > Infectious Disease Modelling (Smith)
UniBasel Contributors:Pemberton-Ross, Peter James and Penny, Melissa and Chitnis, Nakul and Smith, Thomas A.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
e-ISSN:2214-109X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:04 Jun 2018 09:18
Deposited On:06 Dec 2017 10:19

Repository Staff Only: item control page