Absolute values of lung function explain the sex difference in breathlessness in the general population

Ekström, Magnus and Schiöler, Linus and Grønseth, Rune and Johannessen, Ane and Svanes, Cecilie and Leynaert, Benedicte and Jarvis, Deborah and Gislason, Thorarinn and Demoly, Pascal and Probst-Hensch, Nicole and Pin, Isabelle and Corsico, Angelo G. and Forsberg, Bertil and Heinrich, Joachim and Nowak, Dennis and Raherison-Semjen, Chantal and Dharmage, Shyamali C. and Trucco, Giulia and Urrutia, Isabel and Martinez-Moratalla Rovira, Jesús and Sánchez-Ramos, José Luis and Janson, Christer and Torén, Kjell. (2017) Absolute values of lung function explain the sex difference in breathlessness in the general population. The European respiratory journal, 49 (5). p. 1602047.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/55379/

Downloads: Statistics Overview


Activity-related breathlessness is twice as common among females as males in the general population and is associated with adverse health outcomes. We tested whether this sex difference is explained by the lower absolute forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) in females.This was a cross-sectional analysis of 3250 subjects (51% female) aged 38-67 years across 13 countries in the population-based third European Community Respiratory Health Survey. Activity-related breathlessness was measured using the modified Medical Research Council (mMRC) scale. Associations with mMRC were analysed using ordered logistic regression clustering on centre, adjusting for post-bronchodilator spirometry, body mass index, pack-years smoking, cardiopulmonary diseases, depression and level of exercise.Activity-related breathlessness (mMRC ≥1) was twice as common in females (27%) as in males (14%) (odds ratio (OR) 2.21, 95% CI 1.79-2.72). The sex difference was not reduced when controlling for FEV1 % predicted (OR 2.33), but disappeared when controlling for absolute FEV1 (OR 0.89, 95% CI 0.69-1.14). Absolute FEV1 explained 98-100% of the sex difference adjusting for confounders. The effect was similar within males and females, when using FVC instead of FEV1 and in healthy never-smokers.The markedly more severe activity-related breathlessness among females in the general population is explained by their smaller spirometric lung volumes.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 May 2018 09:38
Deposited On:14 Jun 2017 14:00

Repository Staff Only: item control page