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Menopause is associated with accelerated lung function decline

Triebner, Kai and Matulonga, Bobette and Johannessen, Ane and Suske, Sandra and Benediktsdóttir, Bryndís and Demoly, Pascal and Dharmage, Shyamali C. and Franklin, Karl A. and Garcia-Aymerich, Judith and Gullón Blanco, José Antonio and Heinrich, Joachim and Holm, Mathias and Jarvis, Debbie and Jõgi, Rain and Lindberg, Eva and Moratalla Rovira, Jesús Martínez and Muniozguren Agirre, Nerea and Pin, Isabelle and Probst-Hensch, Nicole and Puggini, Luca and Raherison, Chantal and Sánchez-Ramos, José Luis and Schlünssen, Vivi and Sunyer, Jordi and Svanes, Cecilie and Hustad, Steinar and Leynaert, Bénédicte and Gómez Real, Francisco. (2017) Menopause is associated with accelerated lung function decline. American journal of respiratory and critical care medicine, 195 (8). pp. 1058-1065.

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Official URL: http://edoc.unibas.ch/55141/

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Abstract

Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and osteoporosis and may impair lung function. Lung function decline has not previously been investigated in relation to menopause.; To study whether lung function decline, assessed by FVC and FEV1, is accelerated in women who undergo menopause.; The population-based longitudinal European Community Respiratory Health Survey provided serum samples, spirometry, and questionnaire data about respiratory and reproductive health from three study waves (n = 1,438). We measured follicle-stimulating hormone and luteinizing hormone and added information on menstrual patterns to determine menopausal status using latent class analysis. Associations with lung function decline were investigated using linear mixed effects models, adjusting for age, height, weight, pack-years, current smoking, age at completed full-time education, spirometer, and including study center as random effect.; Menopausal status was associated with accelerated lung function decline. The adjusted mean FVC decline was increased by -10.2 ml/yr (95% confidence interval [CI], -13.1 to -7.2) in transitional women and -12.5 ml/yr (95% CI, -16.2 to -8.9) in post-menopausal women, compared with women menstruating regularly. The adjusted mean FEV1 decline increased by -3.8 ml/yr (95% CI, -6.3 to -2.9) in transitional women and -5.2 ml/yr (95% CI, -8.3 to -2.0) in post-menopausal women.; Lung function declined more rapidly among transitional and post-menopausal women, in particular for FVC, beyond the expected age change. Clinicians should be aware that respiratory health often deteriorates during reproductive aging.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Thoracic Society
ISSN:0003-0805
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:06 Jun 2017 12:17
Deposited On:06 Jun 2017 12:17

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