The structure of the homeodomain and its functional implications

Gehring, W. J. and Muller, M. and Affolter, M. and Percival-Smith, A. and Billeter, M. and Qian, Y. Q. and Otting, G. and Wuthrich, K.. (1990) The structure of the homeodomain and its functional implications. Trends in Genetics, Vol. 6, no. 10. pp. 323-329.

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Official URL: http://edoc.unibas.ch/dok/A5258969

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The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:30

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