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Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery

Mastellos, Dimitrios C. and Reis, Edimara S. and Ricklin, Daniel and Smith, Richard J. and Lambris, John D.. (2017) Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery. Trends in Immunology, 38 (6). pp. 383-394.

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Official URL: http://edoc.unibas.ch/55051/

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Abstract

Complement dysregulation underlies several inflammatory disorders, and terminal complement inhibition has thus far afforded significant clinical gains. Nonetheless, emerging pathologies, fueled by complement imbalance and therapy-skewing genetic variance, underscore the need for more comprehensive, disease-tailored interventions. Modulation at the level of C3, a multifaceted orchestrator of the complement cascade, opens up prospects for broader therapeutic efficacy by targeting multiple pathogenic pathways modulated by C3-triggered proinflammatory crosstalk. Notably, C3 intervention is emerging as a viable therapeutic strategy for renal disorders with predominantly complement-driven etiology, such as C3 glomerulopathy (C3G). Using C3G as a paradigm, we argue that concerns about the feasibility of long-term C3 intervention need to be placed into perspective and weighed against actual therapeutic outcomes in prospective clinical trials.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ricklin)
UniBasel Contributors:Ricklin, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1471-4906
e-ISSN:1471-4981
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:20 Oct 2017 07:34
Deposited On:20 Oct 2017 07:34

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