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A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

Freytag, Virginie and Carrillo-Roa, Tania and Milnik, Annette and Sämann, Philipp G. and Vukojevic, Vanja and Coynel, David and Demougin, Philippe and Egli, Tobias and Gschwind, Leo and Jessen, Frank and Loos, Eva and Maier, Wolfgang and Riedel-Heller, Steffi G. and Scherer, Martin and Vogler, Christian and Wagner, Michael and Binder, Elisabeth B. and de Quervain, Dominique J.-F. and Papassotiropoulos, Andreas. (2017) A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory. Nature Communications, 8. p. 15193.

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Abstract

Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P<0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P=0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2041-1723
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:10 Sep 2018 17:01
Deposited On:02 Oct 2017 13:20

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