Cellular prion protein PRPC and ecto-5'-nucleotidase are markers of the cellular stress response to aneuploidy

Domingues, Patrícia Henriques and Nanduri, Lalitha S. Y. and Seget, Katarzyna and Venkateswaran, Sharavan V. and Agorku, David and Viganó, Cristina and von Schubert, Conrad and Nigg, Erich A. and Swanton, Charles and Sotillo, Rocio and Bosio, Andreas and Storchová, Zuzana and Hardt, Olaf. (2017) Cellular prion protein PRPC and ecto-5'-nucleotidase are markers of the cellular stress response to aneuploidy. Cancer Research, 77 (11). pp. 2914-2926.

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Official URL: http://edoc.unibas.ch/54880/

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Aneuploidy is a hallmark of most human tumors, but the molecular physiology of aneuploid cells is not well characterized. In this study, we screened cell surface biomarkers of ~300 proteins by multiparameter flow cytometry using multiple aneuploid model systems such as cell lines, patient samples and mouse models. Several new biomarkers were identified with altered expression in aneuploid cells, including overexpression of the cellular prion protein CD230/PRPC and the immunosuppressive cell surface enzyme ecto-5'-nucleotidase CD73. Functional analyses associated these alterations with increased cellular stress. An increased number of CD73+ cells was observed in confluent cultures in aneuploid cells relative to their diploid counterparts. An elevated expression in CD230/PRPC was observed in serum-deprived cells in association with increased generation of reactive oxygen species. Overall, our work identified biomarkers of aneuploid karyotypes which suggest insights into the underlying molecular physiology of aneuploid cells.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Nigg)
UniBasel Contributors:Nigg, Erich A.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for Cancer Research
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Oct 2017 09:40
Deposited On:16 Oct 2017 09:40

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