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Low efficacy of albendazole against Trichuris trichiura infection in schoolchildren from Port Elizabeth, South Africa

Müller, Ivan and Beyleveld, Lindsey and Gerber, Markus and Pühse, Uwe and du Randt, Rosa and Utzinger, Jürg and Zondie, Leyli and Walter, Cheryl and Steinmann, Peter. (2016) Low efficacy of albendazole against Trichuris trichiura infection in schoolchildren from Port Elizabeth, South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 110 (11). pp. 676-678.

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Official URL: http://edoc.unibas.ch/54801/

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Abstract

Background: Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. Methods: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). Results: Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). Conclusions: Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
UniBasel Contributors:Müller, Ivan and Utzinger, Jürg and Steinmann, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
ISSN:0035-9203
e-ISSN:1878-3503
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Jun 2018 17:49
Deposited On:20 Apr 2017 13:50

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