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Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD

Heck, Angela and Milnik, Annette and Vukojevic, Vanja and Petrovska, Jana and Egli, Tobias and Singer, Jochen and Escobar, Pablo and Sengstag, Thierry and Coynel, David and Freytag, Virginie and Fastenrath, Matthias and Demougin, Philippe and Loos, Eva and Hartmann, Francina and Schicktanz, Nathalie and Delarue Bizzini, Bernardo and Vogler, Christian and Kolassa, Iris-Tatjana and Wilker, Sarah and Elbert, Thomas and Schwede, Torsten and Beisel, Christian and Beerenwinkel, Niko and de Quervain, Dominique J.-F. and Papassotiropoulos, Andreas. (2017) Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD. Nature Human Behaviour, 1. 0081.

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Official URL: http://edoc.unibas.ch/54776/

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Abstract

Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive  and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
10 Zentrale universitäre Einrichtungen > SciCore
UniBasel Contributors:Papassotiropoulos, Andreas and Escobar Lopez, Pablo and Sengstag, Thierry
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2397-3374
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Jun 2018 08:24
Deposited On:04 Jul 2017 13:43

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