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Diazo compounds for the customization of important biomolecules

Fei, Na. Diazo compounds for the customization of important biomolecules. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_12120

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Abstract

The selective modification of native biomolecules such as nucleic acid, signaling molecules, and peptides offers new tools for investigation biological processes. These chemically modified analogs, radiolabeled analogs, fluorescent or affinity tags can be used to label, modify, or pull-down a molecule of interest to probe its function. Among these chemical modifications, diazo compounds are the most versatile building blocks for the customization of diverse biomolecules. In chapter 1, I discuss briefly the properties of diazo compounds and their application in chemistry and chemical biology. The transition-metal catalyzed XHI reaction of stabilized diazo compounds is used later in chapter 2 and the alkylation reaction of unstabilized diazo compounds with BrØnsted acids is used in chapter 3.
Advisors:Gillingham, Dennis and Seebeck, Florian
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Gillingham)
UniBasel Contributors:Fei, Na and Gillingham, Dennis
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:12120
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (143 Seiten)
Language:English
Identification Number:
Last Modified:22 Jan 2018 15:52
Deposited On:17 May 2017 07:23

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